Shimadzu Việt Nam - Trung Son T.S.S.E Scientific Equipment & Tourist Joint Stock Company

Joint Stock Company

Shimadzu Vietnam - Trung Son T.S.S.E Scientific Equipment & Tourist Joint Stock Company is an Exclusive Distributor of SHIMADZU, a famous brand of analytical instruments, since 2000 in Viet Nam

A powerful new tool for research and development in nanotechnology and life sciences, and for measuring fine bubbles.
 

  • Evaluation of the dispersion and aggregation characteristics of particles is realized with a wide measurement range and in real time.
  • The SALD-7500nano was developed to provide accurate and high-sensitivity measurement of low concentration or high-light absorption nano particles. It achieves sensitivity in the nano area about ten times higher as compared to conventional instruments. In addition, low concentration samples of less than 1ppm can be measured.
  • Enables measurement of fine bubbles (micro bubbles from 100 nm to 60 μm), and allows real-time tracing of the changes in the bubble diameter.
  • This system enables the evaluation of sub-visible particles included in biopharmaceuticals. Special options can be added to create an aggregation property evaluation system for biopharmaceuticals.

 


Wide Measurement Range : 7 nm to 800 μm
From primary particles to sub-visible particles and contaminants

  • Changes in particle size across the 7 nm to 800 μm measurement range can be continuously measured using a single light source, single optical system and single measurement principle.
  • Since a primary particle and an aggregate and contaminant can be measured with one system, the aggregation properties by a dispersion condition can be checked.

The evaluation of the dispersion and aggregation characteristics of the particles is realized with a wide measurement range and in real time.

1-Second Minimum Serial Measurement Time. Real time monitoring

  • By incorporating a single light source, which does not require switching, and the wide-angle detection method, the measurement time can be reduced to a minimum of 1 second. In addition, the particle size distribution can be displayed in real time at 1-second intervals.
  • Serial observations of the dispersion, cohesion or dissolution reaction processes are possible at 1-secondintervals, and these results can be saved. Functions for statistical processing and 3D display of the particle reaction processes offer multifaceted analyses and evaluations.
  • Connecting the flow cell directly to the fine bubble generator enables in-line real-time monitoring of the changes in fine bubbles.


Measure Concentrations from 0.1 ppm to 20%

  • Compared to other instruments, the SALD-7500nano permits measurements across an extremely broad concentration range of 0.1 ppm to 20%.
  • The particle size of fine particles, particularly nano particles, varies with the concentration.
    The dispersion and coagulation of nano particles can be observed while altering the concentration.
  • Accurate analysis of samples in which the particle size distribution changes with dilution is possible, as measurements can be conducted on the undiluted solution or after minimal dilution. For example, commercial hand creams, face creams, and rinses can be measured with hardly any pretreatment.

Measurement of Small Sample Amounts

  • Drainage of a small quantity of a suspension liquid is adequate since the SALD-BC75 batch cell permits analysis of a volume of just 5 cm3. Most organic solvents can be used.
  • A combination of the SALD-HC75 high-concentration sample measurement system with special glass slides featuring a shallow indentation permits measurement on just 15 micro liters.

Hardware

 General Specifications
Measurement principle Laser Diffraction Method
Measurement range 7 nm (0.007 μm) to 800 μm (when using sampler)
7 nm (0.007 μm) to 400 μm (when using batch cell)
30 nm (0.03 μm) to 280 μm (when using high-concentration sample unit)
    Note 1: The measurement range varies according to the shape etc. of the particle.

 Measurement unit : SALD-7500nano
Light source Semiconductor laser (Wavelength 405 nm)
Light detector Detector elements for violet semiconductor laser Total 84 elements
(78 forward, 1 side, 5 back)
System compliance Class 1 Laser Product, CE
Required power supply AC 100 V±10%, 1 A, 50/60 Hz
Dimensions & weight Approx. 680 × D280 × H430 mm, Approx.32 kg
Operation environment Temperature : 10 to 30°C , Humidity : 20 to 80% (no condensation)
    Note 2: Reference sample and USB cable (2 m) supplied as standard
     Note 3: Ultrasonic cleaning instruments are needed for the measurement of reference sample.


  

 Sampler : SALD-MS75
Dispersing bath Capacity : 100 / 200 / 300 mL
Sonicator Frequency : about32 kHz, output : about 40 W
Liquid pump Radial pump, maximum flow rate 2000 cm3/min
Liquid pump material Stainless (SUS 304, SUS 316), Tetrafluoroethylene (PTFE),
Perfluoroelastmor (FEP)
Liquid supply pump Diaphragm pump, maximum flow rate : 750cm3/min
Liquid supply pump material Polypropylene
Flow cell Quartz glass
Required power supply AC 100 V±10%, 2 A, 50/60 Hz
Dimensions & weight Approx. W390 × D520 × H430 mm, Approx.18 kg
Operating environment Temperature: 10 to 30°C, Humidity: 20 to 80% (no condensation)
    Note 4: USB cable (2 m) supplied as standard 

 Batch Cell : SALD-BC75
Cell material Quartz glass
Required liquid volume Approx. 5 cm3
Stirrer mechanism Up-and-down movement of blade
Dimensions & weight Approx. W100 × D120 × H140 mm, Approx. 0.8 kg
Operating environment Temperature: 10 to 30°C, Humidity: 20 to 80% (no condensation)

 High-concentration Sample Measurement System : SALD-HC75 
Cell material Borosilicate glass
Required liquid volume Approx. 0.15 cm3
Dimensions & weight Approx. W20 × D100 × H9 mm, Approx. 0.2 kg
Operating environment Temperature: 10 to 30°C, Humidity: 20 to 80% (no condensation)

Software

 WingSALD II
Measurement and Data Display Functions
Measurement of Particle Size Distribution Allows measurements using measurement assistant unction (interactive process based on SOP) and manual mode
Automatic Calculation of Refractive Index Automatic calculation by Light Intensity Distribution Reproduction (LDR) method based on specified substance name or range
Real-time Display Particle size distribution / Light intensity distribution simultaneous display
Recalculation of Particle Size Distribution Max. 200 data batch calculation or individual data calculation
Display of Particle Size distribution Data Max. 200 data overlay graph or individual data graph
Display of Light Intensity Distribution Max. 200 data overlay graph or individual data graph
Diagnostics/Adjustments Self-diagnostic functions
Statistical Data Processing Max. 200 data (Max. 200 data overlay graph)
Time Series Analysis Max. 200 data
3-Dimensional Graph Max. 200 data
Data Transfer via Clipboard Image Output, Image Output
Data Sorting Sort by file name, sample ID, sample number, or refractive index.
Output Conditions
Particle Size Distribution (μm) Number of Divisions Fixed 51 / 101 divisions / Optional (can be set by user) 51 divisions * 10 tables
Particle Mass Distribution (%) Number of Divisions Fixed 51 divisions, Optical (can be set by user) 51 divisions * 10 tables
Dimension of Particle Amount Count, length, area or volume
Expression of Cumulative Distribution Undersize, oversize
Expression of Data Frequency q, q / Δ×, q / Δlog×
Smoothing Level 10 Level
Distribution Function Fitting Rosin-Rammler distribution, logarithmic Gaussian distribution
Data Shifting ±10 levels
Report Functions Batch output possible by selecting single data (template 6), overlay data ( template 5), statistical data, time-series data, or 3D data
Data Analysis
Scattering Angle Evaluation Max. 200 data overlay graph or individual data graph
Data Conversion Function Emulation of particle distribution data by other instruments or measuring principles
Mixing Simulation Function Max. 6 points
Data Connection Function 2 data connections
Continuous Measurements Function Measurement interval: 1 s min., Save up to 200 data points
Note 5: The Light Intensity Distribution Reproduction (LDR) method calculates the refractive index from the conformity between the measured light intensity distribution pattern and the light intensity distribution data reproduced (calculated) from the particle size distribution data. LDR is a proprietary method developed by Shimadzu. Two papers have been published on this method. It is sometimes called the "Kinoshita Method" at academic conferences.